When you see people on the street, at a glance, only a few will ever stand out from the crowd. Be it due to their mannerisms, the way they dress or just their overall feel when compared to the bland and common background.
In RPG’s, these usually turn out to be the quest givers, special contacts or even story hooks designed to stand out so that the party has a clear sense of direction.
Aka, How to think outside of the box and get away with it.
Consider the following. The house Reyne of Castamere royally pissed off the Lannisters. They end up fighting and the last of the Reyne retreat into their main fortress known for its subterranean systems, defenses and living areas. The fort is an absolute pain to take and could sustain them for a long time. A siege could prolong the war for far too long, being costly and an assault would likely end up with high casualties and loss for the Lannister Army. Tywin Lannister knew this and ended up deciding on a third option. Close off any and all entries/exits to the fort, leaving only a small opening for the massive amounts of water from a nearby river, which he had diverted into the fort. Flooding and killing every Reyne inside, ending the war and suffering no extra loss in the process.
Before you choose your system,
before you dream up your antagonist or end boss,
before there is even a mention of classes and sheets,
There is a talk you need to have with your players.
You may already have certain wants and interests for a possible campaign.
But to have an interesting and engaging game for your players, you will need to involve them in the creation of your world. Sit them down and spend some time on hearing them out. This can vary from group to group. From an hour to several sessions. If you can’t meet up in person, try and at least get a discord or skype call going. This will save you some trouble.